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Scholars Academic Journal of Pharmacy | Volume-7 | Issue-07
Protective Effect of Cimetidine, Isosorbide Dinitrate & Vitamin C in Experimental Model of Acute Liver Injury
Faruk H. Al-Jawad, Waleed K. Abdulsahib, Zaid Al-Attar, Jinan A. Al-Hussaini
Published: July 30, 2018 |
140
87
DOI: 10.21276/sajp.2018.7.7.3
Pages: 308-312
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Abstract
Acute liver injury is a serious state of severe extensive damage of liver tissue
caused by various reasons. It is experimentally induced by CCl4 the hepatotoxic agent.
Forty healthy rabbits were involved in the present study. They were allocated in five
groups. Each group was given one of the following drugs: Cimetidine, Isosorbide
dinitrate, Vitamin C & distilled water two hours before administration of CCl4, in addition
to control group. The same doses of the tested drugs were continued for five days after
CCl4 administration. The effect of drugs was evaluated at two occasions 24 and 120 hours
after ALI induction on the basis of biochemical analysis of the liver function tests as well
as histopathological examination to liver of treated animals. The study showed that all the
tested drugs produced significant reduction in SALT, SALP, SAST & TSB with a
significant elevation of TSP levels as compared with treated control group. The
histological examination showed clear improvement in the sections of liver tissue that
supports the effect of these drugs on the liver. All tested drugs proved to have
hepatoprotective effect of varying degree on ALI model in the rabbits.