DOI: 10.21276/sajp.2018.7.7.3

Pages: 308-312

Acute liver injury is a serious state of severe extensive damage of liver tissue caused by various reasons. It is experimentally induced by CCl4 the hepatotoxic agent. Forty healthy rabbits were involved in the present study. They were allocated in five groups. Each group was given one of the following drugs: Cimetidine, Isosorbide dinitrate, Vitamin C & distilled water two hours before administration of CCl4, in addition to control group. The same doses of the tested drugs were continued for five days after CCl4 administration. The effect of drugs was evaluated at two occasions 24 and 120 hours after ALI induction on the basis of biochemical analysis of the liver function tests as well as histopathological examination to liver of treated animals. The study showed that all the tested drugs produced significant reduction in SALT, SALP, SAST & TSB with a significant elevation of TSP levels as compared with treated control group. The histological examination showed clear improvement in the sections of liver tissue that supports the effect of these drugs on the liver. All tested drugs proved to have hepatoprotective effect of varying degree on ALI model in the rabbits.