DOI: 10.36347/sjmcr.2017.v05i09.005

Pages: 532-533

Leiomyomas or fibromyomas , commonly called as fibroids are the most common uterine tumours of smooth muscle origin, often admixed with variable amount of fibrous tissue component. About 20% of women above the age of 30 years harbour uterine myomas of varying size. Vast majority of them are benign and cause no symptoms. Malignant transformation occurs in less than 0.5% of leiomyomas. Symptomatic cases may produce abnormal uterine bleeding, pain, symptoms due to surrounding structures and infertility. The cause of leiomyomas is unknown but the possible stimulus to their proliferation is oestrogen. This is evidenced by increase in their size in pregnancy and high dose estrogen therapy and their regression following menopause and castration. Other possible factors implicated in its etiology are human growth harmone and sterility.