DOI: 10.36347/sjmcr.2017.v05i09.007

Pages: 537-539

The tubulo-interstitial nephritis and uveitis syndrome (TINU syndrome) affects adolescent females preferentially, and it is typically characterized by the association of tubulo-interstitial nephritis and anterior bilateral uveitis. However, it may have different atypical presentations. It can be seen in male, in adults, without renal insufficiency or with a posterior uveitis. We report three cases of atypical TINU syndrome. We reported two out of three adult patients (16, 60 and 62 years of age), two of whom were female and one male. The first patient had a panuvéitis of the left eye and a posterior uveitis of the right eye. The second patient presented bilateral panuveitis with retinal vasculitis. The third patient had a bilateral anterior uveitis recurrent. The three patients had proteinuria, glucosuria, aseptic leukocyturia without renal insufficiency. Renal biopsy showed Tubulo-interstitial nephritis with no sign of vasculitis or glomerular involvement. The etiological investigation did not find any cause (infection, medication, systemic illness). The patients received a local and general corticosteroid therapy associated in one case with Methotrexate, which has resulted in rapid improvement for all three patients. This clinical case report highlights some important features of TINU syndrome, including the increasing incidence of disease in male and adult patients, the possibility of a posterior involvement of uveitis, and clinical presentation without kidney failure. Extensive studies are needed to elucidate the cause and pathogenesis of this syndrome for better management.