DOI: 10.21276/sajp.2018.7.9.2

Pages: 407-413

Transdermal drug delivery system (TDDS) is one of the novel drug delivery systems coming under the category of controlled drug delivery, in which the aim is to deliver the drug through the skin in a predetermined and controlled rate. Conventional dosage forms have significant drawbacks of poor bioavailability and repeated dosing due to hepatic first pass metabolism. Transdermal delivery has many advantages over conventional drug delivery, it avoids hepatic first pass metabolism, potentially decreases side effects and improves patient compliance. This review gives the idea about anatomy physiology of skin, component of TDDS, advantages and disadvantages, and evaluation test for TDDS. The present drug delivery is highly significant if compared to oral route for less side effect, better bioavailability and longer duration of action. Due to good nature of skin is the greatest challenge that has to be overcome for successfully delivery of the drug molecules to the systemic circulation via this route. This article gives the information of recent trends in the area of TDDS to increase the release pattern of drug and related things which is beneficial for patient.