DOI: 10.36347/sasjm.2023.v09i04.026

Pages: 348-351

Neuroblastoma is a malignant tumor characterized by great clinical heterogeneity, ranging from spontaneous regression to progressive tumor evolution. It is already known that the prognosis of neuroblastoma varies according to the age of the child at the time of diagnosis, the stage of the tumor and the amplification of the oncogene MYCN, but there are certainly other factors involved not yet elucidated. Indeed, several teams of researchers are exploring other avenues, immunological, genetic and molecular biology, with the aim of better understanding this phenomenon of spontaneous regression. We report a case of neuroblastoma aged 6 months, and classified as stage 1, having spontaneously evolved towards regression with a review of the literature to underline the crucial importance of further research on this subject to better understand the mechanisms and factors intervening in this favorable evolution with the aim of improving the management and prognosis of neuroblastoma in general, including those classified as high risk.