DOI: 10.21276/sajp.2018.7.10.3

Pages: 442-451

Pharmaceutical corporations round the globe have continually been within the urge of discovering innovative blockbuster medicine for numerous ailments by outlay billions of bucks for the drug discovery programmes. With the development of various molecules pharmaceutical science has gained a lot of success. However, the newly discovered molecules suffer various drawbacks such as poor aqueous solubility, lack of suitable bioavailability etc. The metabolism of API by cytochrome P450 (CYP) DMEs within the gut wall and within the liver is the major process which is responsible for reduced bioavailability of drug. Additionally to the present, EDTs like P glycoprotein (P gp), multidrug resistant associated protein (MRP) are also liable for reduced bioavailability of the therapeutically active medication, particularly metastatic tumor medication. Therefore, a certain alternative is needed which can enhance the bioavailability of these drug molecules. Bioenhancers plays a vital role in modifying the pharmacokinetic and pharmacodynamic profile of these drugs. A bioenhancer is an agent which when co-administered with the drug, enhances its bioavailability. Herbal bioenhancers play an important role in enhancing the bioavailability and efficacy of various categories of medicine, like antihypertensives, anticancer, antiviral, antitubercular and antifungal medication at low doses.