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Scholars Academic Journal of Pharmacy | Volume-7 | Issue-10
Solubility and Bioavailability Enhancement of Lurasidone Hydrochloride by SMEDDS
R.Shyamsunder, B.Kusum
Published: Oct. 30, 2018 | 113 106
DOI: 10.21276/sajp.2018.7.10.5
Pages: 456-459
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Abstract
The purpose of the present study is to prepare SMEDDS of Lurasidone Hydrochloride. The SMEDDS were prepared by using Propylene glycol dicaprate as oil phase and TPGS and TBCP were selected as emulsifiers, the formed SMEDDS were evaluated for different test. Based on the invitro drug release studies it is confirmed that the increase in the dissolution profile of the SMEDDS when compared to the pure API, which directly implies that increase in the bioavailability of the Lurasidone Hydrochloride.