DOI: 10.21276/sajp.2018.7.12.3

Pages: 474-479

The objective of the study was to evaluate the anti-inflammatory effect of Lagerstroemia lanceolata W. leaf methanolic extract along with quantitative determination of phenolic and flavonoid compounds. Quantitative determination of phenolic compounds present in Lagerstroemia lanceolata W. leaves was done by the modified Folin-Ciocalteau method. Acute oral toxicity of methanolic extract of Lagerstroemia lanceolata W. leaves was carried out. Anti-inflammatory effect was studied with the dose of 100, 200 and 400 mg/kg, p.o by carrageenan induced paw edema in rats. Quantitative analysis of L. lanceolata leaf extracts was performed in which the Total phenolic content was determined for ethyl acetate extract (3.472 mg/100 mg of dried extract) & methanolic extract (2.090 mg/100 mg of dried extract) which is compared against standard gallic acid. Total flavonoid content of methanolic extract is 1.475 mg/100 mg of dried extract which is compared against standard quercitin. Methanolic extract of L. lanceolata leaf showed a significant anti-inflammatory activity. The results of the experimental study confirmed that methanolic extracts of Lagerstroemia lanceolata W. has good quantity of phenolic and flavonoidal compounds present which may be responsible for its anti-inflammatory effect.