DOI: 10.21276/sajp.2018.7.12.7

Pages: 511-514

Nauclea latifolia has been used in the management of malaria in the Burkina and despite its application in ethnomedicine, there is dearth of scientific evidence to justify the acclaimed prophylactic antimalarial usage of the plant. The aim of this study was designed to determine the antimalaria, immunostimulatory activities and toxicological effects of the polyphenol-rich fractions of leaves from Nauclea latifolia in animal model. The in vivo antimalaria was conducted on P. berghei infected albino mice by following 4-day test and Curative tests. The effect of oral administration of the polyphenol-rich fractions on biochemical and haematological parameters did not show any significant effect (P < 0.05).The polyphenol-rich fractions of leaves from Nauclea latifolia contains antimalaria and immunostimulant substances which help to reduce parasitaemia and the results of the biochemical and hematological parameters show that the polyphenol-rich fractions is non-toxic. Further studies needed to identify and characterize the potent molecules that suppress the malaria parasite for new drug therapies in view of growing resistance to malaria.