DOI: 10.21276/sajp.2018.7.12.8

Pages: 503-510

Hypertension is the most common cardiovascular disease with elevation of either systolic or diastolic arterial blood pressure. To investigate the possible cardiovascular effects of citrus sinensis, nigella sativum, astemizole in comparison with atenolol & frusemide in induced hypertensive rabbits & to anticipate their mechanism of action. Forty nine healthy domestic rabbits were involved in this study they were allocated to seven groups. Dexamethasone and hypertonic saline were given to the all groups to induce hypertension, after that to each group was given one of the followings citrussinensis, nigella sativum, alcohol, astemizole, atenolol and frusemide to examine their effect on the systolic and diastolic blood pressure, heart rate, blood flow and urine output. Citrus sinensis, nigella sativum, astemizole, atenolol & frusemide produced significant lowering effect to systolic and diastolic blood pressure. Astemizole and atenolol significantly decreased the heart rate. Citrus sinensis, nigella sativum, astemizole, atenolol & frusemide reduced blood flow significantly.