DOI: 10.21276/sajp.2019.8.1.1

Pages: 1-10

Transdermal drug delivery systems (TDDS) are polymeric patches containing dissolved or dispersed drug that deliver the active pharmaceutical ingredient at a constant rate through skin. Transdermal delivery has made an important contribution to medical practice by bypassing the side effects related to oral delivery and hypodermic injections. The principle of TDDS is that they could provide controlled drug delivery over a prolonged period of time. TDDS can be designed to input drug at appropriate rate to maintain plasma-drug levels for maximum therapeutic efficacy. The success of all the transdermal systems depends on the ability of the drug to permeate skin by crossing the biological barriers in sufficient quantities to achieve its desired pharmacological action. The advantage of transdermal drug delivery system is that it is painless technique of administration of drugs and can be withdrawn whenever necessary.