DOI: 10.21276/sajp.2019.8.1.4

Pages: 20-22

A seizure is a paroxysmal event due to abnormal excessive or synchronous neuronal activity in the brain. Epilepsy is a condition in which the patient has recurrent seizure due to a chronic, underlying process. Parkinsonism is the second common neurodegenerative disorder followed by Alzheimer's disease. The Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V). Defines Drug Induced Parkinsonism (DIP) as the presence of resting tremor, muscular rigidity, akinesia or bradykinesia developing within few weeks of starting or raising the dose of medication or after reducing the dose of antiparkinsonian agent. A male patient of age 75years was admitted with complaints of generalized weakness and mild fever for 2 days. While assessing the patient, it was found that the patient has the history of complex partial seizures and is on phenytoin. The drug blood level which was more than the therapeutic level of the drug and the radiologic finding reinforce the findings. The adverse effect was confirmed using Narango’s Algorithm and WHO-UMC Causality system. Even though the radiological findings are still persisting, the clinical symptoms have been relieving with the stoppage of drug.