DOI: 10.21276/sajp.2019.8.2.1

Pages: 30-37

The study aimed to investigate the wound healing activity of the seeds of Dolichos lablab, Phaseolus lunatus, and Glycine soja. In the present study the aqueous extracts of the seeds were orally administered to the Sprague Dawley rats. Evaluation of wound healing activity was done using the incision and excision wound models. In each model, group I served as the control group, group II as the test group treated with Dolichos lablab extract, group III as the group treated with Phaseolus lunatus extract and group IV with Glycine soja extract. Incision wound model rats were treated for 10 days and the wound healing activity was assessed by the tensile strength and histopathological studies of the granulation tissue. Excision wound model rats were treated until the wounds were completely closed. In this model, wound healing activity was assessed by the rate of wound closure and free radical scavenging activity was assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. In both models, hydroxyproline content in the scab was determined. The results of the study indicated that the extract of Dolichos lablab possessed better wound healing and antioxidant activity than Phaseolus lunatus and Glycine soja extracts.