DOI: 10.21276/sajp.2019.8.2.2

Pages: 38-43

Antihypertensive effect of Telmisartan is result of it’s action by specific blockage of angiotensin II receptors. The aim of current study was the application of the validated UV-spectrophotometric method for determination of Telmisartan at λ = 298 nm in 99.98 % ethanol. UV-VIS diode array spectrophotometer was used. From the homogenized tablets of Telmisartan tabl. 80 mg accurately were measured samples, containing an amount, equivalent to 80 mg Telmisartan and were dissolved to 100.0 ml with 99.98 % ethanol in volumetric flasks. From the obtained solutions, an aliquot parts of 1.0 ml were diluted separatelly with the same solvent to 100.0 ml. Data for Chauvenet’s criterion are lower than maximum permissible value (U = 1.73; N = 6), which was applied for the assessment of the need for the removal of sharply different results. Analytical parameter precision was proved by the fact, that all results for the quantities in model mixtures and in tablets correspond to the relevant confidence interval: model mixtures: 80.06 mg  81.34 mg; tablets 80 mg: 77.79 mg  81.09 mg. Standard deviations were lower than 1.2; related standard deviations were lower than 1.6 % and relative errors were lower than 0.7 %. The validated method can be applied for the determination of Telmisartan in dosage drug preparations.