DOI: 10.21276/sajp.2019.8.3.3

Pages: 74-85

Mucoadhesive buccal films containing three layers (mucoadhesive layer, Nanosuspension containing layer and backing membrane) were incorporated with Eprosartan mesylate nanosuspension. Formulation and evaluation of nanosuspension incorporated mucoadhesive buccal films of Eprosartan mesylate for bioavailability enhancement by avoiding first-pass metabolism. Buccal route of drug delivery provides the direct access to the systemic circulation through the jugular vein bypassing the first pass hepatic metabolism leading to high bioavailability. Eprosartan mesylate -loaded nanosuspension was prepared by a precipitation–ultrasonication method with varying concentrations of the polymer. nanosuspension have emerged as one of the most promising dosage forms for formulation of water insoluble and sparingly soluble drugs Nanosuspension consist of hydrophobic drug particles in the nano range (100– 1000 nm) dispersed in a hydrophilic medium (usually water) which are stabilized with the help of polymers, surfactants or a mixture of both. The low particle radius and enlarged surface area of nanosuspension lead to a consequent improved rate of dissolution that can contribute to increased concentration gradient and thus absorption of low soluble but highly permeable drugs. The formulation showed negative zeta potential of -12.6 mV and was analyzed for size and morphology.