DOI: 10.21276/sajp.2019.8.4.2

Pages: 115-120

This study aimed to evaluate the ionic disturbs of acetal extract of Entandrophragma angolense (Meliaceae) in rabbits. E. angolense is a plant used in the traditional treatment of diabetes and several diseases in the south-east of Coast Ivory. In addition to this antidiabetic activity, this plant rich in polyphenolic compounds has an antioxidant potential that could be beneficial in the management of diseases related to oxidative stress. For this study, different batches of rabbits were injected with increasing doses of acetal extract of E. angolense. Then changes in serum calcium, magnesium, chloride, sodium and potassium were evaluated. This study indicated that the acetal extract of E. angolense with doses between 312.5 and 5000 mg / kg body weight (bw) in rabbits causes a significant variation (P <0.05) of potassium and calcium serum concentrations. But there is no significant change (P> 0.05) of magnesium, chloride, and sodium and serum concentration. Finally, this study suggests that a reduction of the dose (2500 mg / kg) and time of treatment (4 weeks) may help to avoid ionic disturbs other time. This dose of 2500 mg /kg/bw which is much higher than the therapeutic dose, confer on E. angolense a safety margin very interesting.