DOI: 10.21276/sajp.2019.8.4.8

Pages: 156-161

The human heart is an organ that pumps blood throughout the body via the circulatory system, supplying oxygen and nutrients to the tissues and removing carbon dioxide and other wastes. Thus, to maintain a healthy heart is a crucial factor for overall health and well-being. But because of today’s food habits and stress conditions can eventually lead to various heart ailments. These conditions can be cured with cardiotonic agents. Before introducing drugs into market, that drug has to check for its safety and efficacy. For studying the drug activity, both in vitro and in vivo screening models have been developed in the past years. These Systems measures the ability of the test drugs to prevent or cure heart problems in laboratory conditions and on experimental animals. This review reveals some of such animal model to check the activity of cardiotonic drugs.