DOI: 10.21276/sajp.2019.8.4.9

Pages: 162-168

Purpose: The main objective of present research investigation is to formulate sustained release tablets of Simvastatin using different polymers. Simvastatin, an anti-hyperlipidemic agent belong BCS class-II agent. Methods: The SR tablets of Simvastatin were prepared employing different concentrations of HPMCK15M, xanthan gum and carbopol and tablets are prepared by using direct compression method. Results and discussion: Total six formulations are designed and evaluated for hardness, friability, thickness, % drug content and In-vitro drug release. From the results it was concluded that all the formulations are found to be within the pharmacopeia limits and in-vitro dissolution profiles of all formulation are subjected to different kinetic models, the statistical parameters like slope intercept and regression coefficient were calculated. Conclusion: It was concluded that the polymeric combination of HPMCK15M with xanthan gum in the ratio 1:1 was able to retarded the release of Simvastatin from the tablets to the24th hour and showed an ideal release pattern necessary for sustained release tablet.