DOI: 10.21276/sajp.2019.8.5.9

Pages: 224-236

Moxidectin is a macrocyclic lactones derivative are probably the anti-parasitic agents most widely used in the treatment of food producing animals, poultry, aquaculture and crops. A number of alternative products such abamectin, doramectin, emamectin, eprinomectin, milbemycin and selamectin, have been marketed since. The increase in the number of macrocyclic lactones drugs, there has been a steady increase in the number of published analytical methods for determination of their residues. Methodologies for determination of moxidectin residues in biological matrices are described in terms of extraction and clean-up methods used for different matrices. Detection systems for determination of moxidectin residues are discussed with a particular emphasis placed on new developments in screening technologies and different chromatography with fluorescence or mass spectrometry.