DOI: 10.21276/sajp.2019.8.5.10

Pages: 237-253

Benzimidazole nucleus plays an important role in several categories of clinical agents such as antimicrobials, antivirals, antiparasitic, anticancer, anti-inflammatory, antioxidants, proton pump inhibitors, antihypertensives, anticoagulants, immunomodulators, hormone modulators, CNS depressants, and antidiabetics, etc. Many researchers coin it as a crucial moiety for the development of innovative therapeutic agents. Wide-ranging substituents on the benzimidazole nucleus show a varied spectrum of biological activities. In order to understand the current position of the benzimidazole nucleus in medicinal chemistry research, this review summarized the chemistry as well as pharmacological activities of benzimidazole scaffold. This discussion will further help in the development of novel benzimidazole compounds.