DOI: 10.36347/sjmcr.2018.v06i11.018

Pages: 977-979

Drug Rash with Eosinophilia and Systemic Symptoms, currently considered as a systemic reaction with a life-threatening and drug-induced visceral manifestation, has never been described with a chemotherapy drugs. A 52 years-old women with metastatic uterine leiomyosarcoma under chemotherapy second line gemcitabine, presents an extensive erythema with a 38 c° fever, two weeks after chemotherapy. The laboratory studies revealed a mild increase of inflammatory markers, mild anemia, and hyper-leukocytosis and hepatic cytolysis. The histology of skin’s biopsy finds an important lymphocytic infiltrate. The diagnosis is Drug Rash with Eosinophilia and Systemic Symptoms: DRESS syndrome. The patient was treated with corticosteroid therapy, with favorable evolution, the gemcitabine was permanently discontinued. The exact cause is unknown, most likely polyfactorial, It is described as a genetic predisposition. The definitive discontinuation of the drug product in question and systematic emergency corticosteroid therapy is compulsory.