DOI: 10.21276/sajp.2019.8.6.1

Pages: 276-281

The aim of the present investigation was to design and optimize pulsatile drug delivery of model antihypertensive drug enalapril. The developed formulations were optimized using 4-factor 3- level Box-Behnken statistical design. The rationale behind this Box Behnken design based on the salient principles of design of experiments and quality by design approach. Three independent variables viz., ethyl cellulose (X1), sodium alginate (X2), HPMC (X3) and three dependent variables viz., percentage drug release at 4 hrs (Y1), percentage drug release at 8 hrs (Y2) and percentage drug release at12 hrs (Y3) were selected for the study. Contour plots were constructed to further elucidate the relationship between the independent variables and dependent variables. The polynominal equations and contour plots developed using Box Behnken design allowed us to prepare Pulsatile tablets with optimum responses.