DOI: 10.36347/sjmcr.2019.v07i01.011

Pages: 34-35

Glycemic instability which is common among patients treated with insulin is incapacitating because of the repeated episodes of hypoglycemia that are often related to dietetic errors, insulin overdose or excessive physical effort but rarely to an auto-immune etiology that is due to the presence in the serum of the patient of anti-insulin or anti receiver- insulin antibodies. We report the case report of a 58 years old female patient, Who is a Slow type 1 diabetes carrier, and has been on premixed human insulin for 4 years, the patient presented repeated episodes of hypoglycemia : both nocturnal and late postprandial, The rate of anti-insulin antibodies was positive higher than 50 IU / ml (NR <0.4). The patient was started on corticosteroids containing prednisolone (1mg/kg/j) and insulin analogue. The course was marked by the disappearance of the hypoglycemic episodes.