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Scholars Journal of Medical Case Reports | Volume-7 | Issue-01
The Silent Somatotropic Adenoma: When Immunohistochemistry Has the Last Word
Nassiba Elouarradi, Ghizlane Elmghari, Nawal Elansari
Published: Jan. 30, 2019 |
189
180
DOI: 10.36347/sjmcr.2019.v07i01.018
Pages: 59-61
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Abstract
Silent somatotropic adenomas are pituitary adenomas with immunohistochemical expression of growth hormone (GH), but without clinical signs of acromegaly, and for which GH and insulin-like growth factor-1 (IGF1) levels are normal or slightly increased. For these adenomas, only histopathological examination reveals positive immunostaining for GH. However, their exact frequency is not known. We report the case of a patient who showed no signs of acromegaly with normal IgF1 levels and in whom only the anatomopathological study allowed the postoperative diagnosis of silent somatotropic adenoma.