DOI: 10.36347/sjmcr.2019.v07i02.005

Pages: 116-120

Central pontine and extrapontine myelinolysis is a demyelinating disease of the central nervous system.It is the classical presentation of Osmotic demyelination syndrome (ODS). We report a case of Central pontine and extrapontine myelinolysis in a pregnant patient, who presented electrolyte disturbances due to hyperemesis gravidarum. The patient developed tetraparesis and dysarthria following a rapid correction of hyponatremia.The diagnosis of central pontine and extrapontine myelinolysis was made by brain MRI which showed demyelinating lesions in the pons and in splenium of the corpus callosum. In the reported case, the rapid correction of hyponatremia in it alone does not seem to be the only factor implicated, the rest of the electrolyte disturbances, especially hypokalemia seems likely increased the vulnerability of glial cells to osmotic stress. The treatment was symptomatic. The outcome was favorable marked by regression of dysarthria with partial recovery of motor deficit.