DOI: 10.36347/sjds.2023.v10i05.003

Pages: 91-96

Summary: Periapical lesions, inflammatory reactions caused by bacterial infections in the periapical area of teeth, require effective treatment for optimal healing. Non-setting Ca (OH)2 has been utilized as a medicament in endodontic procedures to promote the healing of periapical lesions. This systematic review aims to evaluate the effect of non-setting calcium hydroxide on the healing of periapical lesions. Non-setting calcium hydroxide is commonly used in endodontic procedures for its antimicrobial and tissue-healing properties. Understanding its effectiveness in promoting periapical lesion healing is crucial for clinical decision-making and improving patient outcomes. A comprehensive literature search was conducted using electronic databases (PubMed, Embase, and Cochrane Library) to identify relevant studies published up to September 2021. The search strategy included keywords related to non-setting calcium hydroxide, periapical lesions, endodontic treatment, and healing. Both experimental and clinical studies assessing the effect of non- setting calcium hydroxide on periapical lesion healing were included. Data were extracted and assessed for quality and bias using appropriate tools. The initial search yielded a total of 378 articles, of which 12 studies met the inclusion criteria. The studies included in this review consisted of both in vitro and in vivo experimental models, as well as clinical trials. The outcomes assessed varied among the studies, including radiographic evaluation, histological analysis, and clinical examination. The majority of the included studies reported positive effects of non-setting calcium hydroxide on periapical lesion healing. These effects were attributed to its antimicrobial activity, promotion of tissue repair, and induction of mineralized tissue formation. Based on the available evidence, non-setting calcium hydroxide appears to have a beneficial effect on the healing of periapical lesions. However, due to the heterogeneity ...