DOI: 10.36347/sjmcr.2019.v07i04.004

Pages: 280-283

Myelodysplastic/ myeloproliferative neoplasm with ring sideroblasts and thrombocytosis is a rare overlap syndrome, no formal guidelines for the management of this disease exist. We report the case of a 64 years old male patient who was admitted for myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis with mutation in the Janus Kinase 2 gene and hyperdiploid clone. Lenalidomide given for a period of 6 months performed to maintain a normal blood platelet count with, for the first time, sustained platelet response 24 months after discontinuation of treatment.