DOI: 10.21276/sajp.2019.8.7.8

Pages: 365-375

In this work a new attempt was made to enhance the solubility, poor water solubility and slow dissolution rate are issues for majority of upcoming and existing biologically active compounds. The aim of present work was to increase the dissolution rate of Rosuvastatin Calcium, a poorly water soluble drug and hence improve its oral bioavailability by Nanosuspension technology. In the present work Nanosuspension is made by nanoprecipitation technique in the presence of Poloxamer 407 as a surfactant, Tween 80 as a wetting agent and HPMC as a stabilizer. The formulated nanosuspensions were characterised by Scanning Electron Microscope (SEM) and FTIR. The formulations were evaluated for drug content, entrapment efficacy, Zeta potential and In-Vitro dissolution. SEM results showed the particle size of the formulated nanosuspensions in nanosize. FTIR spectrum revealed that there are no interactions between drug and carriers. Finally it was concluded that formulating poorly soluble drugs in the form of Nanosuspension would be a promising approach in delivery of poor water soluble drugs by oral route in a simple and effective way.