DOI: 10.36347/sjmcr.2019.v07i05.012

Pages: 351–354

Hyalinizing clear cell carcinoma (HCCC), so-called clear cell carcinoma, not otherwise specified (CCC (NOS)), of the salivary glands is a rare and low-grade malignant tumor. HCCC has a vast differential diagnosis including various clear cell-containing tumors, such as epithelial-myoepithelial carcinoma, mucoepidermoid carcinoma, and myoepithelial carcinoma. HCCC is presently classified as a “clear cell adenocarcinoma” by the AFIP and as “clear cell carcinoma, not otherwise specified (NOS)” by the World Health Organization (WHO). It is considered by the WHO to be a diagnosis of exclusion.We reported a case of HCCC of the minor salivary gland of the buccal mucosa which was clinically diagnosed as pleomorphic adenoma. A 66-year-old woman had presented with a gradually growing and indolent mass in the left buccal mucosa for about two years. The tumor measured approximately 1.5 cm in diameter and was diffuse hard, smooth. Histopathological findings revealed proliferating tumor cells with clear cytoplasm surrounded by hyalinizing stroma with perineural invasion. Immunohistochemical stains revealed these tumor cells to be positive for cytokeratin but negative for myoepithelial ones. These findings confirmed the diagnosis of HCCC.