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Scholars Academic Journal of Pharmacy | Volume-8 | Issue-08
Formulation and Evaluation of Nanoemulsion for Targeting and Systemic Delivery of Diclofenac Sodium
Neha Agnihotri, Girish Chandra Soni, Sunil Kumar Prajapati, Dilip Kumar Chanchal, Afrin Khan, Sakshi Tiwari
Published: Aug. 17, 2019 |
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DOI: 10.21276/sajp.2019.8.8.1
Pages: 376-393
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Abstract
The aim of the present study was to prepare a nanoemulsion of diclofenac sodium for reduce side effects and improved
oral bioavailability to treat arthritic conditions and investigate the potential of a nanoemulsion formulation for
targeting and systemic delivery of diclofenac sodium. Various oil-in-water nanoemulsions were prepared by the
titration emulsification method. The nanoemulsion area was identified by constructing pseudoternary phase diagrams.
The prepared nanoemulsions were subjected to different thermodynamic stability tests. The nanoemulsion
formulations that passed thermodynamic stability tests were characterized for viscosity, droplet size, transmission
electron microscopy, size and zeta potential, and refractive index. The physical stability of nanoemulsion was studied
using autoclaving, centrifugal, desorption (dilution effect) stresses and on storage. The selected formulations, F1, F2
and F3, were relatively stable during centrifugal stress, dilution stress and on storage. The cumulative percentage drug
release from F1, F2 and F3 showed more release in pH 6.8 phosphate buffer than in pH 1.2 HCl. During oral
bioavailability studies, the nanoemulsion showed higher serum concentrations than a suspension. The relative
bioavailability of the nanoemulsion formulations F1, F2 and F3 were found to be that of F4 suspension and were
statistically significant. Of all, the nanoemulsion (F3) was superior in improving bioavailability, when compared with
plain emulsion (F1) and (F2). The study helps in designing the oral nanoemulsions to improve the oral bioavailability
of diclofenac sodium.