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Scholars Academic Journal of Pharmacy | Volume-8 | Issue-08
Solanum Xanthocarpum Ethanol Extract Inhibits Mast Cell Degranulation in OVA-Sensitized Animals
Poonam Arora, Ansari SH, Iram Nazish
Published: Aug. 21, 2019 |
117
103
DOI: 10.21276/sajp.2019.8.8.6
Pages: 421-423
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Abstract
Aim of present study was to investigate the effects of Solanum xanthocarpum Schrad and wendl on degranulation of
mast cells in abdominal mesentery of male albimo rats. 4 groups of animals (6 animals per group) were used. All
animals except group I were sensitized and challenged with ovalbumin (40 mg/rat) followed by treatment with
standard dexamethasone or S. xanthocarpum ethanolic whole plant extract (0.5 mg/kg b.wt) (SXE). %Protection
offered by drugs against mast cell degranulation was studied in isolated mesentery stained with toluidine blue. Number
of mast cells with extruded granules and entact cells were counted under microscope (x45). Allergen treatment
resulted in significant increase in number of degranulated mast cells compared to normal control group. After
treatment with SXE for 28 days significant decrease (55±4.22%) in number of mast cell with extruded granules
compared to ovalbumin control group were found. However, the effects were not found to be significant in animals
treated with standard dexamethasone compared to ovalbumin control group. Results of study show powerful mast cell
stabilizing property of S. xanthocarpum ethanolic whole plant extract.