DOI: 10.36347/SJMCR.2019.v07i12.002

Pages: 732-733

POEMS syndrome is a rare multisystemic disease that occurs in the setting of a plasma cell dyscrasia. Peripheral neuropathy is the dominant clinical feature of this disorder and is often the inaugural sign. We report the case of a 46-year-old patient, followed-up for chronic polyradiculoneuropathy, admitted in our department for etiological assessment of an ascites with elevated protein content and important weight loss. The diagnosis of POEMS syndrome was established in the presence of two major criteria associated to several minor criteria (organomegaly, ascites, papillary edema and skin changes, hypothyroidism). Dexamethasone was the initial treatment used for our patient then it was combined to thalidomide. The clinical outcome was good.