DOI: 10.36347/SAJP.2019.v08i10.001

Pages: 461-464

A simple, precise, accurate, sensitive and economic spectroscopic method has been developed for estimation of Vandetanib from bulk by least square treatment of Fourier transform infrared spectrometric method with help of data obtained at wave number corresponding to C-F group at 1211.10cm- , aromatic C=C at 1499.76 cm-1, C-H alkane at 2905.45 cm-1, CH2 bend at 1415.56 cm , alkenes out of plane bend at 991.28 cm-1, aromatics out of plane bend at 842.14cm-1, C=C Alkene at 1617.78 cm-1 , C-O at 1145.57 cm-1 , N-H stretch at 1574.19 cm-1, C-N amines 1332.42 cm-1, C-Br at 772.18 cm-1.In order to validate method Linearity, Accuracy and precision studies were carried out and result were satisfactory obtained. The drug at each of the 80 %, 100 % and 120 % levels showed good recoveries that is in the range of 97.00 to 99.00% for the method, hence it could be said that the method was accurate. Limit of detection (LOD) and limit of quantitation (LOQ) were determined for the method. The method was validated by the International Conference on Harmonization. All validation parameters were within the acceptable limit. The developed method was successfully applied to estimate the amount of vandetanib in pharmaceutical formulation.