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Scholars Academic Journal of Pharmacy | Volume-8 | Issue-11
Evaluation of Antioxidant Activity of Aqueous and Ethanolic Extracts of Myrianthus Holstii (Cecropiaceae) Barks, in Vitro
Silue Kalamourou, Doumbia Idrissa, Nimaga Daouda, Yéo Sounta Oumar, Yapi Houphouet Felix, N’guessan Jean David, Djaman Allico Joseph
Published: Nov. 29, 2019 |
143
136
DOI: 10.36347/SAJP.2019.v08i11.007
Pages: 508-513
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Abstract
The purpose of this study is to evaluate the antioxidant activity of Myrianthus holstii (Cecropiaceae), a plant used in
traditional medicine against gastroenteritis in western Côte d'Ivoire (Man). The extraction yields of the ethanolic
extract (EE) and the aqueous extract are respectively 6.4% and 7.95%. Determination of the total phenol content by the
colorimetric method gave the following results: EAeC (27.67 ± 1.45 mg EAG / g of extracts) and EEec (428.70 ± 1.67
mg EAG / g of extracts). The flavonoid assay using the AlCl3 aluminum chlorides method gave the following results:
EAec (12 ± 0.57 EQ / g extracts) and EEec (53.33 ± 3.75 EQ / g of extracts). The evaluation of the antioxidant activity
of extracts was carried out according two methods: the free radical scavenging by the DPPH and the measurement of
the reducing power (FRAP). The results obtained indicate that ethanolic extract contains more polyphenolic
compounds than the aqueous extract. Ethanolic extract (EAec) antioxidant properties (EEec, IC50 = 03.20 ± 0.45
mg/mL) are also greater than those of the aqueous extract (EAec, IC50 = 43.30 ± 0.40 mg/mL). This antioxidant
activity which remains close to that of vitamin C (01.25 ± 0.02) could represent an additional asset in the management
of pathologies linked to oxidative stress.