DOI: 10.36347/sajp.2019.v08i12.004

Pages: 538-543

The reducing of gastrointestinal glucose production and absorption through the inhibition of carbohydrate digesting enzymes such as α-amylase and α-glucosidase is a good antidiabetic therapeutic approach. The aim of this study was to evaluate the Chloroform, Dichloromethan, Ethyl acetate and Methanol extracts of N. Canescens and H. auriculata whole plants for their in vitro antidiabetic activity. Our result suggests that all extracts exhibit dosedependent increase in percentage inhibitory activity on α-amylase and α-glucosidase enzymes. The best α-amylase IC50 value of 403.50 ± 4.48 μg/mL was obtained with the Chloroform extract of H. auriculata while the Methanol extract of N. canescens with an IC50 value of 507.50 ± 4.55 μg/mL. Regarding the α-glucosidase, the best IC50 value of 326,12 ± 2.86 μg/mL was obtained with H. auriculata Chloroform extracts followed by N. canescens Methanol extract with an IC50 value of 364.40 ± 3.48 μg/mL. Acarbose was used as a standard drug.