DOI: 10.36347/sajp.2019.v08i12.006

Pages: 547-551

Background: The present study is aimed to formulate and evaluate an antidiabetic herbal tablet containing Oryza sativa L. var Joha Rice, Dillenia indica and Syzygium cumini Lam. of Assam. Material & Methods: The plants materials were obtained from local area and authenticated by botanist and extracted using solvent ethanol using soxlet apparatus. The poly herbal tablet is prepared using extract of (Oryza sativa (seed) L., Dillenia indica (fruit) and Syzygium cumini (Lam.) (seed) various excipients viz., carbopol, ethylcellulose, MCC, dibasic calcium phosphate and PEG-4000 by granulation method and evaluated by using Weight variation, Hardness, Friability, Thickness and Disintegration Time. Results: Preformulation studies of prepared six formulation powder were studied and showed Angle of repose in the ranges from 22.32 to 34.65, bulk density in the range from 0.43 to 0.56 g/cm3, tapped density in the range from 0.54 to 0.65 g/cm3, Carr’s Index in the range 13.84 to 23.21%, hausner ratio in the range of 1.16 to 1.30 and. Loss on drying (LOD) in the range of 0.84 to 1.04%. Tablet formulations were evaluated and found weight variation within limit with average theoretical weight 400mg, hardness of in the ranges from 4.44 to 4.71 Kg/cm2, % Friability was within range of 0.68 to 0.76, disintegration time in the range of 12 min 32 sec to 23 min 20 sec, thickness was found 4.5 ±0.01 to 4.5 ±0.02 and found formulation remain stable in stability testing. Conclusion: The poly herbal tablet is prepared using extract of (Oryza sativa (seed) L., Dillenia indica (fruit) and Syzygium cumini (Lam.) (seed) and formulation passed pharmaceutical dose form evaluation tests.