DOI: 10.36347/sasjm.2023.v09i06.022

Pages: 668-674

Background: Patients with acute respiratory failure have traditionally been evaluated for non-invasive mechanical ventilation (NIV) based on clinical evaluation and changes in blood gases, with NIV support pressures manually adjusted by an operator. Bilevel positive airway pressure-spontaneous/timed (BiPAP S/T) with average volume assured pressure support (AVAPS) uses a fixed tidal volume that automatically adapts to a patient's needs. Objective: To see the effective of non-invasive mechanical ventilation with average volume assured pressure support (AVAPS) in patients with chronic obstructive pulmonary disease with acute exacerbation. Materials and Methods: This single-center prospective study was carried out at the Gazi Medical College (GMC), Khulna, Bangladesh, in the department of medicine. The research's participants were all admitted between December 1, 2021, and January 1, 2023. The trial included all patients with acute exacerbations of chronic obstructive pulmonary disease. Age, gender, and disease severity were determined using the APACHE II scoring system. A structured proforma was used to collect data. The percentage and absolute number were used to express all category data. All numerical continuous data were reported as mean standard deviation. SPSS version 23 was used to analyze the data. All tests were evaluated using a 95% confidence interval, and a P value of 0.05 was deemed significant. Results: The mean MBS, NRS, dyspnea/comfort scale, respiration rates, systolic blood pressure, and diastolic blood pressure- post treatment were statistically significant (p <0.05) when compared to pretreatment in the BiPAP S/T with AVAPS group. Mean PaCO2, MBS, NRS, dyspnea/comfort scale, heart rate, respiration rates, and systolic blood pressure- post treatment were statistically significant (p <0.05) when compared to pretreatment in the BiPAP S/T group. Conclusion: BiPAP S/T with AVAPS promotes a quicker return to awareness in patients with chronic .......