DOI: 10.36347/sjams.2023.v11i06.021

Pages: 1109-1114

Background: Acne is a multifactorial skin lesion and a persistent inflammatory disorder of the pilosebaceous units. One of the most common skin problems, acne vulgaris, which predominantly affects teenagers but can affect anyone at any age, is treated by dermatologists. Objective: The goal of the current study was to assess the profile of changes in ALT, AST, and lipid profiles (TGs, LDL, and HDL) in these patients. Methodology: This cross-sectional study was conducted at tertiary care hospital Dhaka District from June 2020 to July 2022 in the Department of Dermatology. A total of 200 patients were participate in the study. Patients aged more than 15 years, both male and female and patients with diagnosed acne were included in the study. Severely ill patients and not willing to participate were excluded from the study. Data collection was done after approval of protocol using a semi-structured questionnaire through face to face interview. Data were analyzed using a computer programme SPSS 25.0 version. Result: The mean age of male was 22 (±6.7) while in case of female was 24 (±4.5). Minimum age of the patients was 18 year and maximum was 45 year. 75% of the respondents were female and 25% were male. The mean ((±SD)) RBC was 4.9 (0.5)×106 /mL, WBC was 8.4 (3.5)×103 /mL and Hb was 14.3 (1.7)×106 /mL, in case of female the Hb was 12.6 [1.5]× 106 /mL and 14.9 (1.1)×106 /mL for male. In this present study, we discovered that individuals who received isotretinoin medication was statistically significant increases in both TG and LDL levels. Additionally, we discovered statistically significant decreases in HDL levels. In our study, patients who received isotretinoin treatment had liver enzymes that were less altered than lipids. The clinical classification was unaffected, although there were statistically significant increases in AST levels. ALT levels raised as well, but the variations were not statistically significant. Conclusion: Although severe laboratory alterations