DOI: 10.36347/sajp.2020.v09i02.003

Pages: 68-74

Progeria is a rare syndrome, with an estimated incidence of 1 per 250,000 births. It is a fatal, genetically determined disease of childhood characterized by dramatic, premature aging that occurs at about 8 to 10 times the normal rate of aging. Because of this accelerated aging, a child of ten years will have similar respiratory, cardiovascular, and arthritic conditions that a 70-year-old would have. Progeria is the most radical of the ageing illnesses. Although children with progeria has the appearance of premature aging or senility, the term is misleading because reported cases of progeria has not manifested most physical or biochemical aspects of old age. Many children with progeria appear normal at birth and then progressively, and rather rapidly, develop the characteristic features during early childhood. Although first described in the 1880s, only approximately 100 cases of progeria are reported in the international literature. Most of the classical clinical features of progeria as seen 4 or 5 years old age. In a few study there has been a history of maternal illness during pregnancy is main causes of progeria but no specific illness appearing to be significant. The goal of this study was to determine sign and symptoms, investigate mechanisms that cause of HGPS and how to treat the occasional illness of progeria.