DOI: 10.36347/sajp.2020.v09i02.006

Pages: 86-89

Montelukast sodium is a selective, orally active leukotriene receptor antagonist drug used in the treatment of asthma in adults and children. It is rapidly absorbed after administration with a mean bioavailability of 73%. There is a need to develop formulations which overcomes problems of Tablet as a dosage form, such as difficulty in swallowing, inconvenience in administration while travelling and dyspghagia. Hence in the present study an attempt has been made to prepare fast dissolving tablets of Montelukast sodium with enhanced dissolution rate. The tablets were prepared by direct compression method using with superdisintegrants. Direct compression is the most simple and economical method used in tableting. The simplicity of the direct compression process is apparent from a few steps involved in the manufacture of tablets as compared to wet granulation. The tablets were evaluated for hardness, drug content, friability and were found as per the specification. Drug content estimation showed that more than 95% of the drugs was present. The highest drug release was obtained with the formulation F9 containing higher concentration of super disintegrants such as Sodiun starch glycolate and Crosspovidone.