DOI: 10.36347/sjams.2023.v11i07.012

Pages: 1272-1277

Introduction: Hypothyroidism is a common metabolic disorder in general population. Hypothyroidism is a commonly encountered health problem in Bangladesh and morbidity and mortality toll due to cardiovascular disease resulting from hypothyroidism is quite high. Hypothyroidism, dyslipidaemia and hyperhomocysteinemia are recognized risk factor for atherosclerosis and cardiovascular disease. Aim of the Study: The aim of this study was to evaluate the association between plasma Homocysteine level and atherogenic Index of plasma in patients with hypothyroidism. Methods: This was a case-control study and conducted in the Department of Biochemistry in cooperation with Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh during the period from January, 2012 to December, 2013. In our study, we included 60 newly diagnosed hypothyroid individuals as case and 60 euthyroid individuals as control. Result: In this study, most of the participants were female (62%) compared to male (38%) and we found the mean age of the case and control group was 34.31 ± 11.77 years and 32.42 ± 12.51 years. Mean serum homocysteine was found significantly higher in case group (19.00 ± 7.58 µmol/L) than control group (9.59 ± 1.91µmol/L).Mean AIP was found significantly higher in case (0.75 ± 0.27) than control (0.35 ± 0.20). We found 49 (81.67%) cases were within increased risk group of atherogenesis where as in control group it was 28 (46.67%).In present study, mild hyperhomocysteinemia was found in 80% cases and moderate hyperhomocysteinemia in 13.3% cases where as in control group it was 10% & 0% respectively. Conclusion: In this study, we found that total plasma homocysteine level was significantly increased in recently diagnosed hypothyroidism and was normal in control groups. We also found that hypothyroidism is associated with high atherogenic index and hyperhomocysteinemia which causes premature atherosclerosis.