DOI: 10.36347/sajb.2016.v04i08.006

Pages: 634-636

Typhoid fever continues to remain a major public health problem, especially in developing due to poor sanitation and personal hygiene. Salmonella enteric serovarstyphi and Paratyphi A&B are predominantly known to cause enteric fever. A changing antibiotic susceptibility pattern of Salmonella typhi and Salmonella Paratyphi A& B and emergence of multi drug resistance has increased to a great concern. This study was conducted at the department of microbiology in Dr. RML Hospital, New Delhi to investigate the antibiotic susceptibility pattern of Salmonella typhi and Salmonella Para typhiA&B. Blood culture samples were collected from suspected enteric fever patient and tested microbiologically by standard procedure. Antibiotic susceptibility test was performed by Kirby-Bauer disc diffusion method and results were interpreted according toCLSI guidelines. Out of the total 19,037 blood samples, 228 Salmonella isolates were isolated. Of these, 206 (90.3%) were S.typhi, 21 (9.21%) isolates were S.paratyphi A and 1 isolate (0.44%) was S.paratyphi B. Among the tested antibiotics S. typhi was susceptible towards amikacin (97.5%), Chloramphenicol (89.4%), Ceftriaxone (87.8%), cotrimoxazole (87.8%), gentamicin (72.4%) followed by ciprofloxacin (10.3%) and nalidixic acid (9.1%). 2.92% of S. typhi isolates showed multidrug resistance. A considerable variation was observed in the antimicrobial susceptibility pattern of S.typhiand S.paratyphi A & B. Hence antibiotic susceptibility test must be sought before instituting appropriate therapy to prevent fromfurther emergence of drug resistance.