DOI: 10.36347/sajb.2016.v04i08.016

Pages: 684-687

Present study was conducted to evaluate the cardioprotective activity of Pandanus odoratissimus leaf extract in rats. 24 Sprague – Dawley rats were used in the study and divided in to 4 groups of 6 each. Isoproterenol (85mg/kg,ip) was used to induce the myocardial infarction in rats. Lipistat (350mg/kg) was used as reference control and 200mg/kg of ethanolic leaf extract of Pandanus odoratissimus was used as evaluate the cardioprotective effect. All the test drugs were administered orally by suspending in 0.1% carboxy methyl cellulose solution once daily for 15 days. On 16th day blood was collected by sinus puncture under anesthesia to estimate cardiac biomarkers Creatinine Phosphokinase and Lactate Dehydrogenase. Animals were sacrificed by excess phenobarbitone, heart was dissected out, homogenized and estimated superoxide dismutase and catalase. Result showed that, the animals pretreated with 200 mg/kg of Pandanus odoratissimus leaf extract significantly decreased the cardiac marker enzyme CPK (P<0.01) and LDH (P<0.05) and increased the levels of SOD (P<0.05) and CAT (P<0.01). form the result it was concluded that, the ethanolic leaf extract of Pandanus odoratissimus exhibited cardioprotective activity against Isoproterenol induced cardiac damage in rats and it may be due to the presence of Isoflavone and carotenoids and its free radical scavenging property.