DOI: 10.36347/sjams.2017.v05i12.006

Pages: 4808-4812

Schizophrenia itself or antipsychotic medications are primarily responsible for the observed increased metabolism disturbances (insulin level and insulin resistance) are not clear. To study insulin level and insulin resistance in drug naive patients with schizophrenia. Thirty one drugs naive patients suffering from first episode of schizophrenia and 40 age and sex matched healthy controls were studied at Peoples Medical College, Bhopal. Illness related variables were rated by Brief Psychiatric Rating Scale (BPRS). Venous blood was collected after overnight fasting and sent for fasting plasma glucose (FPG), serum lipid profile and serum insulin estimation. Plasma glucose was determined by glucose oxidase method, serum insulin was determined by chemiluminescence and insulin resistance was calculated using HOMA-IR [fasting plasma insulin (FPI) (mu U/ml) x (FPG [mg/dl] x 0.055/22.5). Male (52.5%) and female (51.6%) preponderance was observed in control and Drug naïve group respectively. Fasting glucose (mg/dL), insulin level (mu U/ml), insulin resistance, Triglycerides (mg/dL), Cholesterol (mg/dL), HDL (mg/dL), VLDL (mg/dL), LDL (mg/dL) and Risk Ratio in control and Drug naïve group was 85.32 ± 6.04 vs 91.12 ± 7.77 (P=0.0007), 7.98 ± 2.14 vs 11.45 ± 1.84 (P=0.0001), 1.65 ± 0.45 vs 2.56 ± 0.58 (P=0.0001), 87.45 ± 27.5 vs 107.29 ± 40.63 (P=0.01), 167.45 ± 13.93 vs 167.64 ± 18.96 (P=0.96), 42.84 ± 3.69 vs 41.98 ± 4.87 (P=0.40), 17.49 ± 5.50 vs 21.48 ± 8.12 (P=0.007), 107.11 ± 14.44 vs 103.88±18.37 (P=0.40) and 3.91 ± 0.47 vs 4.02±0.59 (P=0.38) respectively. Fasting glucose, fasting insulin level, insulin resistance, VLDL, triglyceride was significantly higher in Drug naïve schizophrenia patients.