DOI: 10.36347/sajp.2020.v09i05.003

Pages: 168-171

Background: Thyroid function abnormalities are relatively common in patients with schizophrenic disorders due to the medical management of the disease with antipsychotic drugs which causes abnormalities in thyroid gland parameters. Objective: The purpose of this study is to explore effect of Quetiapine and Olanzapine on thyroid function tests in a number of schizophrenic patients and to compare the impact of these antipsychotic drugs on thyroid function. Patients and method: A retrospective cross sectional observational study. One hundred and six patients involved in this study allocated into three study arms. Thyroid data, consisting of values for thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), and total thyroxine (TT4) were obtained at baseline and after 12 weeks of treatment through Hakeem Data base. To evaluate differences in TT3, TT4 and TSH concentrations in patients before and after treatment versus control group, one-way ANOVA and unpaired t-tests were used. Values less or equal to 0.05 were considered significant. Results: Drug treatment in schizophrenic patients was associated with decrease of TT3 and TT4 (p < 0.05) and with elevation of TSH (p = 0.05) in both study arms in comparison with the control arm and with baseline data. Conclusion: This study shows that 3 months therapy with quetiapine and olanzapine leads to a abnormalities in thyroid function parameters of schizophrenic patients.