DOI: 10.36347/sajb.2016.v04i09.012

Pages: 761-766

Lipid disorder is well recognized risk factor for cardiovascular disease. The association of lipid derangement with depressive disorder has been a recent focus of research specially in female. The objective of this study was to investigate the serum lipids in female major depressive disorder patients(MDD). This case control study was done in the department of Physiology, Bangabandhu Sheikh Mujib Medical University, Dhaka during 2014. This study included 60 female MDD patients, diagnosed by psychiatrist according to the criteria of diagnostic and statistical manual (DSM IV) and 30 healthy females as control. Fasting blood glucose and Triglyceride (TG) Total cholesterol(TC) and High density lipoprotein cholesterol (HDL) was estimated by commercial diagnostic kit and auto analyser. Low density lipoprotein (LDL), TC/HDL and LDL/HDL was determined by calculation. For statistical analysis, independent sample t test and chi-square test was applied. Odds ratio and confidence interval for atherogenic risk was calculated by SPSS 16 version. Serum level of TG(P<0.001), TC, (P<0.01) HDL(P<0.05), LDL(P<0.05), TC/HDL(P<0.05) and fasting glucose (P<0.001)was significantly higher in MDD compared to control. Elevated fasting glucose, hypertriglyceridemia, hypercholesterolemia, elevated LDL were noted in, 45%, 27%, 20% and 6.7% patients respectively. Elevated level of TC/HDL was found in 34% depressed patients which was significantly higher in MDD. The odds ratio for atherogenic risk I ((increased HDL/LDL) and risk II (LDL/HDL) showed significant association (P<0.05) with MDD patients. This study concluded that lipid and lipoprotein abnormality along with some component of metabolic syndrome is highly prevalent in female MDD patients which identify them as high risk group for CHD or CVD.