DOI: 10.36347/sajb.2016.v04i10.013

Pages: 863-869

Water melon juice contain potent antioxidants such as lycopene in addition to other health promoting bioactive phytochemicals. Overdoses of the analgesic and antipyretic acetaminophen extra represent one of the most common pharmaceutical product poisonings worldwide today. This work was designed to evaluate the effect of watermelon juice in rabbits overdosed with acetaminophen extra using Total cholesterol, Triglyceride, HDL and LDL. Thirty rabbits classified into 6 groups labeled A-F (with C1, C2, E1 and E2) with A as control were investigated. Acetaminophen extra overdosed (1500mg/kg) was administered into some of the rabbits to induce toxicity. Fifteen milliliter of watermelon juice was used to prevent the toxicity. The blood sample collected was used to determine the plasma level of Total cholesterol, Triglyceride, HDL cholesterol and LDL cholesterol were analyzed biochemically by spectrophotometry. The result showed no significant alteration in the plasma level of Total cholesterol, Triglyceride, HDL cholesterol and LDL cholesterol when the rabbits were given 1500mg/Kg of Acetaminophen Extra body weight and also when the rabbits were given water melon juice before or after they were given 1500mg/Kg of Acetaminophen Extra( p>0.05). However, there was a significant increase in the level of plasma Cholesterol following the administration of 1500mg/kg body weight of acetaminophen extra and 15ml/Kg of watermelon juice simultaneously (p<0.05). co-adminisration of 15ml/Kg of watermelon juice and 1500mg/Kg acetaminophen extra could have a synergetic and defective metabolic effect leading increase in plasma cholesterol in rabbits.