DOI: 10.36347/sajb.2017.v05i03.011

Pages: 192-199

Stomach cancer or gastric cancer, is a cancer which develops from the lining epithelium of the stomach. Symptoms of gastric carcinoma generally include dyspepsia, pain in the epigastric region or upper part of the abdomen, nausea, anorexia and loss of appetite. Signs and symptoms in the advanced stages of cancer include severe weight loss, vomiting, difficulty in swallowing and blood in the stools. The cancer may spread from the stomach to other parts of the body by local and distant metastasis through vascular channels, distance spread particularly involves the liver, lungs, skeletal bones, lining of the abdomen and lymph nodes .According to many researchers, the most common cause of gastric carcinoma is infection by the bacterium Helicobacter pylori, which accounts approximately 60% of cases or more. A total of 40 cases were included in this study. CD10 Immmuno-histochemistry marker was used. Out of the 40 cases of gastric carcinomas, 16(40%) cases were of well differentiated, 13(32.5%) cases were of moderately differentiated and 11(27.5%) cases were of poorly differentiated grade. Most of the cases were seen in male patients and the most commonest region involved was pyloric antrum of the stomach. CD10 expression by the stromal cells plays an important role in the pathogenesis of gastric cancer and also that the proliferation of CD10-positive stromal cells is part of the mechanism of metastasis in gastric cancer.