DOI: 10.36347/sajb.2017.v05i05.005

Pages: 348-351

Kidney stone is a common painful condition of multifactorial etiopathogenesis, and calcium oxalate is the commonest component of stone. Traditionally various medicinal plants were used in the treatment of urolithiasis globally due to its least side effects. The present study was undertaken with an aim of evaluating the antiurolithiasis effect of ethanolic leaf extract of Ipomoea reniformis against, ethylene glycol induced urolithaisis in rats. The animals were divided in to 5 groups of 6 animals each. Group I served as normal control and received regular rat food and drinking water ad libitum. Ethylene glycol (0.75%) in drinking water was fed to Groups II-V for induction of renal calculi till 28th day. Group II served as uro lithiatic control, received drinking water and group III received standard antiurolithiatic drug, Cystone (750mg/kg weight) from 15th day till 28th day. Groups IV and V served as curative regimen received ethanolic leaf extract of Ipomoea reniformis (200 and 400 mg/kg, respectively) from 15th day till 28th day once daily by oral route. On 28th day, urine samples were collected from all the groups and analysed Calcium, Phosphate and Oxalate content. Blood was also withdrawn through retro-orbital puncture under phentobarbitone anesthesia; serum was separated and subjected to Creatinine, Uric acid and Urea Nitrogen.