DOI: 10.36347/sajb.2017.v05i10.007

Pages: 732-743

The protective effect of fruit juice of Cucumber and Watermelon on selected biochemical parameters of cadmium induced toxicity on male albino rats was investigated. Forty male rats were divided into eight groups. Group VIII served as normal control while group VII was positive control that was administered with Cadmium only. Groups I to VI received high and low doses of Cucumber and Watermelon juice respectively. Apart from the normal control group, other groups were fed with lard 14days before treatment commenced. Doses of 0.8mg/kg body weight-high dose and 0.4mg/kg body weight-low dose for Cucumber and Watermelon was administered respectively. At the 4th and 6th week, biochemical parameters were assayed. The testes, liver and kidney were submitted for histopathological examination. Results show that pretreatment with Cucumber and Watermelon juice caused a decrease in aspartate transaminase and alkaline phosphatase in the treatment groups after 4 weeks compared to positive control value (35.66±13.32U/L) and (516.66±23.02) respectively. Alanine transaminase values reduced in treatment groups compared to positive control group (16.33±2.31U/L). Urea and Creatinine levels were significantly (P˂ 0.05) reduced in treatment groups compared to positive control of 11.58 ± 1.24mmol/L and 161.4±3.17µmol/L respectively after 4 weeks of pretreatment. Electrolytes were reduced compared to positive control. The group that received low dose of the combination of Cucumber and Watermelon extract showed more significant change than other groups indicating possible dose dependent effect.